Animals
All mice and experimental protocols used in this project has been
approved by Institutional Animal Care and Use Committee for Animal
Experimental Ethics Committee of Northeast Normal University
(NENU/IACUC) and carried out in accordance with recommendations in Guide
for Care and Use of Laboratory Animals of National Institutes of Health
as well. Mice were bred and maintained under specific pathogen-free
condition in animal facility with controlled temperature at 21±1°C,
30%-60% humidity, 12:12 light/dark cycles and free access to food and
water.