ACKNOWLEDGMENTS
This work was financially supported in part or in whole by National Natural Science Foundation of China (81270953), the Natural Science Foundation of Jilin Province (20160101344JC) and Science and Technology Project of Jilin Provincial Education Department (JJKH20180023KJ). The funders had no roles in this study, including study design, data collection, data analysis or decision to publish or preparation of the manuscript. We are grateful to Ms. Huiyan Wu for microinjection and managing mouse colony.