Animals
All mice and experimental protocols used in this project has been approved by Institutional Animal Care and Use Committee for Animal Experimental Ethics Committee of Northeast Normal University (NENU/IACUC) and carried out in accordance with recommendations in Guide for Care and Use of Laboratory Animals of National Institutes of Health as well. Mice were bred and maintained under specific pathogen-free condition in animal facility with controlled temperature at 21±1°C, 30%-60% humidity, 12:12 light/dark cycles and free access to food and water.