3. Interpretation
The authors support their inferences well with detailed and logically
conveyed observations. The only thing I am not totally convinced is the
conclusion of overexpression of Doc2bDN and
Doc2b6A mutants results in short-term depression after
repetitive stimulation. It might be helpful to show the absolute data
rather than only normalized ones for the “recovery” measurements in
figure 5 and 8. Also, if the authors can give some more justifications
of the data showing short-term depression rather than larger initial
peak.