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Radicals as Chiral Catalysts for Asymmetric Radical Cyclization Reactions
  • Quan-Qing Zhao,
  • Min Gu,
  • Jiarong Chen
Quan-Qing Zhao
Jiangsu Ocean University
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Min Gu
Jiangsu Ocean University
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Jiarong Chen
Huazhong Normal University

Corresponding Author:[email protected]

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Abstract

Due to the innate unique highly reactive properties and short life-time, organic free radicals can often serve as promoters or inter-mediates to engage in various radical transformations, which are otherwise difficult to access by ionic pathway-based mechanisms. With the evolvement of radical chemistry, chiral radical catalyzed-transformations have recently emerged as an attractive and ro-bust platform for synthesis of chiral molecules of interest. Herein, we highlight several creative and strategic advances in chiral rad-ical catalyst design, cyclization reaction achievements, and future challenges.