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Single-center experience of LVAD implantation in patients with sickle-cell trait: a retrospective analysis
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  • Elena Grasso,
  • Khalid Al Khamees,
  • Ahmed Ibrahim,
  • hassane abdallah,
  • Mohammed Ibrahim,
  • Omer Sayin,
  • Roberto Lorusso
Elena Grasso
Prince Sultan Cardiac Center Al Hassa

Corresponding Author:[email protected]

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Khalid Al Khamees
Prince Sultan Cardiac Center Al Hassa
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Ahmed Ibrahim
Prince Sultan Cardiac Center Al Hassa
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hassane abdallah
Prince Sultan Cardiac Center Al Hassa
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Mohammed Ibrahim
Prince Sultan Cardiac Center Al Hassa
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Omer Sayin
Istanbul Universitesi Istanbul Tip Fakultesi
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Roberto Lorusso
Maastricht Universitair Medisch Centrum+
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Abstract

Background: The most worrisome complications in patients supported by left ventricular assist device (LVAD) are pump thrombosis, embolism, and bleeding. The actual rate of these events in patients with sickle-cell disease (SCD) has not well investigated. The aim of our study is to evaluate the outcomes of LVAD implantation in patients with sickle-cell hemoglobinopathy at our institution. Methods: This retrospective, observational, single-center study was conducted on patients with sickle-cell trait (SCT), who underwent LVAD implantation using the HeartMate3 LVAD. Results: LVAD devices were implanted in four patients with SCT. All procedures were performed successfully. All patients had uneventful post-implant course. Overall, the mean follow-up time was 25 months (range 21-28 months) and showed an unremarkable post-implant course. There was a significant improvement in hematological markers over the follow-up period. Conclusions: Despite the limited numbers of patients enrolled in this study, our findings indicate that LVAD surgery is safe in SCD patients and offers remarkable clinical improvement. Further studies are needed to provide more evidence regarding this type of patients undergoing LVAD implantation.
25 Aug 2022Submitted to Journal of Cardiac Surgery
25 Aug 2022Assigned to Editor
25 Aug 2022Submission Checks Completed
08 Sep 2022Reviewer(s) Assigned
19 Sep 2022Review(s) Completed, Editorial Evaluation Pending
26 Oct 2022Editorial Decision: Accept