Objective: To evaluate the long-term outcomes of vulvar or vaginal cancer patients undergoing laparoendoscopic single-site inguinal lymphadenectomy (LESS-IL). Design: Prospective cohort study. Setting: Single centre in Zhongda Hospital, Southeast University from July 2018 to April 2021. Population: A total of 16 women diagnosed with vulvar or vaginal cancer. Methods: Women with vulvar or vaginal cancer underwent LESS-IL performed by the same surgeon from July 2018 to April 2021. Main outcome measures: Short- and long-term complications, and oncologic outcomes Results: A total of 16 patients undergoing 28 LESS-IL procedures were identified, among whom 4 underwent unilateral LESS-IL. Median numbers of excised groin lymph nodes were 9.0 (6.5-11.8) and 10.5 (8.3-12.0) in each left and right groin, respectively. Short-term complications occurred in 4 (25%) patients, including 18.7% lymphocele and 6.3% wound infection. Long-term complications regarding lower limb lymphedema appeared in 6 (37.5%) patients. Most of the short- and long-term complications were Clavien-Dindo 1 or 2, accounting for 90% of all postoperative issues. After a median follow-up of 23 (17.3‐31.8) months, only 1 patient (6.3%) had isolated inguinal recurrence at 13 months postoperatively. No local or distant recurrence occurred. Conclusion: Our results suggest that LESS-IL is associated with little incidence of complications and promising oncologic outcomes, further demonstrating the safety and feasibility of LESS-IL technique in patients requiring IL. Keywords Laparoendoscopic single-site inguinal lymphadenectomy, vulvar cancer, vaginal cancer, compliaction, oncologic outcome