Maternal Interleukin-17 and Disease Activity Influence Pregnancy
Outcomes in Women with Psoriatic Arthritis and Ankylosing Spondylitis
Abstract
Objective: We aimed in this study to evaluate the impact of maternal
interleukin -17A and the activity of the illness on pregnancy outcomes
in Psoriatic arthritis (PsA) and ankylosing spondylitis (AS) patients.
Methods: This prospective cohort research was carried out on 48
Psoriatic arthritis and ankylosing spondylitis pregnant women attending
the inpatient and outpatient clinics of Rheumatology & Rehabilitation
and Obstetrics & Gynecology Departments, Faculty of Medicine, Zagazig
university hospitals in Egypt and Yanbu National Hospital in KSA and 30
apparently healthy age- and sex-matched pregnant women between January
1,2018, and December 31, 2019. Results: The study group patients have
higher risk of preterm labour (32‐36 weeks’ gestation) (aRR 1.80, 95%
CI 0.79–4.17), oligohydramnios (aRR 3.15, 95% CI 1.26-8.42), Caesarean
delivery (aRR 1.57, 95% CI 1.41-2.68), and delivering infants small for
gestational age (aRR 7.04, 95% CI 2.36-12.42). There was significant
difference between the control group and the study groups regarding the
level IL-17A. Conclusion: A lot of females with PsA and AS have
uninhibited pregnancy as regards adverse events, but in comparison with
normal pregnancies particularly with high IL-17A during third trimester
we noticed a growing risk of preterm labour, oligohydramnios and
caesarean section.