“ Homology Modeling of Rab11 Protein of Retina involved in
Choroideremia (Homo sapiens) ”
Abstract
Choroideremia (CHM), is caused by a defect on the X gene which prohibits
the body from making RAB Escort Protein-1, or REP-1, which further lead
vision lost. The biological role of RAB Escort Protein-1 (REP-1)
determine by homology modeling. In this research work the structure of
Rab11 was predicted using Geno3d server. Ramachandran plot obtained by
Geno 3-D server to estimate the effect of amino acid. The predicted
structure was visualized through different visualization tools such as
Pymol, Rasmol, and Swiss-pdb viewer. The active site was predicted
through Q-site finder for further drug discovery and development for
said disease.