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Isolated Tricuspid Valve Surgery – Repair Versus Replacement: a Meta-analysis
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  • Panagiotis Sarris-Michopoulos,
  • Alejandro Macias,
  • Constantine Sarris-Michopoulos,
  • Palina Woodhouse,
  • Daniel Buitrago,
  • Tomas Salerno,
  • Michael Magarakis
Panagiotis Sarris-Michopoulos
University of Miami Miller School of Medicine

Corresponding Author:[email protected]

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Alejandro Macias
University of Miami Health System
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Constantine Sarris-Michopoulos
University of Georgia
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Palina Woodhouse
Vanderbilt University School of Medicine
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Daniel Buitrago
University of Miami Miller School of Medicine; Jackson Memorial Hospital; Department of Surgery, Division of Cardiothoracic Surgery
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Tomas Salerno
university of miami miller school of medicine and jackson memorial hospital
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Michael Magarakis
Miami VA Medical Center - University of Miami Miller School of Medicine
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Objective: There is paucity of data on outcomes after isolated tricuspid valve surgery. This meta-analysis aims to compile available data on isolated tricuspid valve surgery and compare isolated tricuspid valve repair (iTVr) with isolated tricuspid valve replacement (iTVR) to elucidate outcomes after tricuspid valve surgery. Methods: A literature search of 6 databases was performed. The primary outcomes was 30-day mortality. Secondary outcomes were early stroke, post-op pacemaker placement, and tricuspid reoperation within 5 years. Publication bias was explored using the funnel plot. Results: Ten retrospective studies involving 1407 patients (iTVr group = 779 patients and iTVR group = 628 patients) were included. A cumulative analysis demonstrated a significant difference favoring iTVr for 30-day mortality [odds ratio – 10 studies (95% confidence interval) 0.34 (0.18-0.66)]; 4.7% versus 12.6%, for iTVr and iTVR, respectively. Post-op pacemaker placement favored iTVr [odds ratio – 6 studies (95% confidence interval) 0.37 (0.18-0.77)]. Although stroke rates and TV reoperation favored iTVr, they did not reach statistical significance. No publication bias was identified. Conclusions: This meta-analysis demonstrates that iTVr has better 30-day mortality and fewer permanent pacemaker placements. Etiology and severity of TR, as well as careful patient selection remain the most important factors for optimal outcomes.
20 Jul 2021Submitted to Journal of Cardiac Surgery
20 Jul 2021Submission Checks Completed
20 Jul 2021Assigned to Editor
10 Aug 2021Reviewer(s) Assigned
18 Aug 2021Review(s) Completed, Editorial Evaluation Pending
07 Sep 2021Editorial Decision: Revise Minor
07 Sep 20211st Revision Received
11 Sep 2021Submission Checks Completed
11 Sep 2021Assigned to Editor
20 Sep 2021Reviewer(s) Assigned
20 Sep 2021Review(s) Completed, Editorial Evaluation Pending
26 Sep 2021Editorial Decision: Accept
09 Nov 2021Published in Journal of Cardiac Surgery. 10.1111/jocs.16131