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Mechanobiological conceptual framework for assessing stem cell bioprocess effectiveness
  • Mee-Hae Kim,
  • Masahiro Kino-oka
Mee-Hae Kim
Osaka University

Corresponding Author:[email protected]

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Masahiro Kino-oka
Osaka University
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The realization of the enormous potential of stem cells requires development of efficient bioprocesses and optimization drawing drawn from mechanobiological considerations. Here, we emphasize the importance of mechanotransduction as one of the governing principles of stem cell bioprocesses, underscoring the need to further explore the behavioral mechanisms involved in sensing mechanical cues and coordinating transcriptional responses. We identify the sources of the intrinsic, extrinsic, and external noise in bioprocess under uncertainty, and discuss criteria and indicators that might assess and predict cell-to-cell variability resulting from environmental fluctuations. Specifically, we propose a conceptual framework to explain the impact of mechanical forces within cellular environment and identify key cell state determinants in bioprocess and discuss their implementation challenges.
24 May 2021Submitted to Biotechnology and Bioengineering
24 May 2021Submission Checks Completed
24 May 2021Assigned to Editor
25 May 2021Reviewer(s) Assigned
30 Jul 2021Review(s) Completed, Editorial Evaluation Pending
30 Jul 2021Editorial Decision: Revise Major
22 Aug 20211st Revision Received
23 Aug 2021Submission Checks Completed
23 Aug 2021Assigned to Editor
27 Aug 2021Review(s) Completed, Editorial Evaluation Pending
27 Aug 2021Editorial Decision: Accept
Dec 2021Published in Biotechnology and Bioengineering volume 118 issue 12 on pages 4537-4549. 10.1002/bit.27929