Located in northern Dominican Republic, the Early Cretaceous Rio Boba mafic-ultramafic plutonic sequence constitutes a lower crust section of the Caribbean island arc, made up by gabbroic rocks and subordinate pyroxenite. Modal compositions, mineral chemistry, whole-rock compositions and thermobarometric calculations indicate that pyroxenites and gabbronorites represent a cumulate sequence formed by fractionation of tholeiitic magmas with initially very low H₂O content in the lower crust of the arc (0.6-0.8 GPa). Melts evolved along a simplified crystallization sequence of olivine ® pyroxenes ® plagioclase ® Fe-Ti oxides. The magmatic evolution of the Rio Boba sequence and associated supra-crustal Puerca Gorda metavolcanic rocks is multi-stage and involves the generation of magmas from melting of different sources in a supra-subduction zone setting. The first stage included the formation of a highly depleted substrate as result of decompressional melting of a refractory mantle source, represented by a cumulate sequence of LREE-depleted IAT and boninitic gabbronorites and pyroxenites. The second stage involved volumetrically subordinate cumulate troctolites and gabbros, which are not penetratively deformed. The mantle source was refractory and enriched by a LILE-rich hydrous fluid derived from a subducting slab and/or overlying sediments, and possibly by a LREE-rich melt. The third stage is recorded in the upper crust of the arc by the Puerca Gorda ‘normal’ IAT protoliths, which are derived from an N-MORB mantle source enriched with a strong subduction component. This magmatic evolution has implications for unravelling the processes responsible for subduction initiation and subsequent building of the Caribbean island arc.